Journal article
Regulation of stem cell pluripotency and neural differentiation by lysophospholipids
SM Pitson, A Pébay
Neurosignals | KARGER | Published : 2009
DOI: 10.1159/000231891
Abstract
Lysophospholipids are bioactive signalling molecules able to act through the binding of their specific G-protein-coupled receptors to exert pleiotropic effects on a wide range of cells. The most widely studied signalling lysophospholipids are lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P). LPA and S1P have been identified to have widespread developmental, physiological and pathological actions in the central nervous system and more recently have been shown to induce biological effects on various stem cell types. This review aims to summarise the current knowledge on LPA and S1P regulation of embryonic and neural stem cell biology. © 2009 S. Karger AG, Basel.
Grants
Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
This work was supported by a Senior Research Fellowship (to S. M. P.), Project Grants 454723 and 508097 from the National Health and Medical Research Council of Australia, the Fay Fuller Foundation and Friedreich Ataxia Research Association. The authors thank Ms. Kathryn C. Davidson, Aude Pebay and Jessie Leung, for their technical assistance in work that lead to the data presented in figures 1, 2 and 4. The authors thank Dr. Paul Verma, Dr. Jun Liu and Prof. James Thompson for providing iPS cell lines.